Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case–control study

Luigi Ferini-Strambi; Wolfgang Oertel; Yves Dauvilliers; Ronald B Postuma; Sara Marelli; Alex Iranzo; Isabelle Arnulf; Högl Birgit; Raffaele Manni; Tomoyuki Miyamoto; Maria-Livia Fantini; Monica Puligheddu; Poul Jennum; Karel Sonka; Joan Santamaria; Marco Zucconi; Paola M V Rancoita; Smeranda Leu-Semenescu; Birgit Frauscher; Michele Terzaghi; Masayuki Miyamoto; Marcus Unger; Karin Stiasny-Kolster; Alex Desautels; Christina Wolfson; Amélie Pelletier; Jacques Montplaisir

doi:10.1007/s00415-014-7317-8

Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case–control study

Luigi Ferini-Strambi, Wolfgang Oertel, Yves Dauvilliers, Ronald B Postuma, Sara Marelli, Alex Iranzo, Isabelle Arnulf, Högl Birgit, Raffaele Manni, Tomoyuki Miyamoto, Maria-Livia Fantini, Monica Puligheddu, Poul Jennum, Karel Sonka, Joan Santamaria, Marco Zucconi, Paola M V Rancoita, Smeranda Leu-Semenescu, Birgit Frauscher, Michele TerzaghiMasayuki Miyamoto, Marcus Unger, Karin Stiasny-Kolster, Alex Desautels, Christina Wolfson, Amélie Pelletier, Jacques Montplaisir

66 Citationer (Scopus)

Abstract

Patients with idiopathic REM sleep behavior disorder (iRBD) are at very high risk of developing neurodegenerative synucleinopathies, which are disorders with prominent autonomic dysfunction. Several studies have documented autonomic dysfunction in iRBD, but large-scale assessment of autonomic symptoms has never been systematically performed. Patients with polysomnography-confirmed iRBD (318 cases) and controls (137 healthy volunteers and 181 sleep center controls with sleep diagnoses other than RBD) were recruited from 13 neurological centers in 10 countries from 2008 to 2011. A validated scale to study the disorders of the autonomic nervous system in Parkinson's disease (PD) patients, the SCOPA-AUT, was administered to all the patients and controls. The SCOPA-AUT consists of 25 items assessing the following domains: gastrointestinal, urinary, cardiovascular, thermoregulatory, pupillomotor, and sexual dysfunction. Our results show that compared to control subjects with a similar overall age and sex distribution, patients with iRBD experience significantly more problems with gastrointestinal, urinary, and cardiovascular functioning. The most prominent differences in severity of autonomic symptoms between our iRBD patients and controls emerged in the gastrointestinal domain. Interestingly, it has been reported that an altered gastrointestinal motility can predate the motor phase of PD. The cardiovascular domain SCOPA-AUT score in our study in iRBD patients was intermediate with respect to the scores reported in PD patients by other authors. Our findings underline the importance of collecting data on autonomic symptoms in iRBD. These data may be used in prospective studies for evaluating the risk of developing neurodegenerative disorders.

Originalsprog	Engelsk
Tidsskrift	Journal of Neurology
Vol/bind	261
Udgave nummer	6
Sider (fra-til)	1112-1118
Antal sider	7
ISSN	0340-5354
DOI	https://doi.org/10.1007/s00415-014-7317-8
Status	Udgivet - jun. 2014

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10.1007/s00415-014-7317-8

Citationsformater

Ferini-Strambi, L., Oertel, W., Dauvilliers, Y., Postuma, R. B., Marelli, S., Iranzo, A., Arnulf, I., Birgit, H., Manni, R., Miyamoto, T., Fantini, M-L., Puligheddu, M., Jennum, P., Sonka, K., Santamaria, J., Zucconi, M., Rancoita, P. M. V., Leu-Semenescu, S., Frauscher, B., ... Montplaisir, J. (2014). Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case–control study . Journal of Neurology, 261(6), 1112-1118. https://doi.org/10.1007/s00415-014-7317-8

Ferini-Strambi, L, Oertel, W, Dauvilliers, Y, Postuma, RB, Marelli, S, Iranzo, A, Arnulf, I, Birgit, H, Manni, R, Miyamoto, T, Fantini, M-L, Puligheddu, M, Jennum, P, Sonka, K, Santamaria, J, Zucconi, M, Rancoita, PMV, Leu-Semenescu, S, Frauscher, B, Terzaghi, M, Miyamoto, M, Unger, M, Stiasny-Kolster, K, Desautels, A, Wolfson, C, Pelletier, A & Montplaisir, J 2014, 'Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case–control study ', Journal of Neurology, bind 261, nr. 6, s. 1112-1118. https://doi.org/10.1007/s00415-014-7317-8

@article{808dca389f2e4c57890e41d259c08ce1,

title = "Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case–control study ",

abstract = "Patients with idiopathic REM sleep behavior disorder (iRBD) are at very high risk of developing neurodegenerative synucleinopathies, which are disorders with prominent autonomic dysfunction. Several studies have documented autonomic dysfunction in iRBD, but large-scale assessment of autonomic symptoms has never been systematically performed. Patients with polysomnography-confirmed iRBD (318 cases) and controls (137 healthy volunteers and 181 sleep center controls with sleep diagnoses other than RBD) were recruited from 13 neurological centers in 10 countries from 2008 to 2011. A validated scale to study the disorders of the autonomic nervous system in Parkinson's disease (PD) patients, the SCOPA-AUT, was administered to all the patients and controls. The SCOPA-AUT consists of 25 items assessing the following domains: gastrointestinal, urinary, cardiovascular, thermoregulatory, pupillomotor, and sexual dysfunction. Our results show that compared to control subjects with a similar overall age and sex distribution, patients with iRBD experience significantly more problems with gastrointestinal, urinary, and cardiovascular functioning. The most prominent differences in severity of autonomic symptoms between our iRBD patients and controls emerged in the gastrointestinal domain. Interestingly, it has been reported that an altered gastrointestinal motility can predate the motor phase of PD. The cardiovascular domain SCOPA-AUT score in our study in iRBD patients was intermediate with respect to the scores reported in PD patients by other authors. Our findings underline the importance of collecting data on autonomic symptoms in iRBD. These data may be used in prospective studies for evaluating the risk of developing neurodegenerative disorders.",

keywords = "Aged, Autonomic Nervous System Diseases, Case-Control Studies, Female, Humans, Male, Middle Aged, Polysomnography, REM Sleep Behavior Disorder, Retrospective Studies, Statistics, Nonparametric",

author = "Luigi Ferini-Strambi and Wolfgang Oertel and Yves Dauvilliers and Postuma, {Ronald B} and Sara Marelli and Alex Iranzo and Isabelle Arnulf and H{\"o}gl Birgit and Raffaele Manni and Tomoyuki Miyamoto and Maria-Livia Fantini and Monica Puligheddu and Poul Jennum and Karel Sonka and Joan Santamaria and Marco Zucconi and Rancoita, {Paola M V} and Smeranda Leu-Semenescu and Birgit Frauscher and Michele Terzaghi and Masayuki Miyamoto and Marcus Unger and Karin Stiasny-Kolster and Alex Desautels and Christina Wolfson and Am{\'e}lie Pelletier and Jacques Montplaisir",

year = "2014",

month = jun,

doi = "10.1007/s00415-014-7317-8",

language = "English",

volume = "261",

pages = "1112--1118",

journal = "Deutsche Zeitschrift fur Nervenheilkunde",

issn = "0939-1517",

publisher = "Springer Medizin",

number = "6",

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TY - JOUR

T1 - Autonomic symptoms in idiopathic REM behavior disorder

T2 - a multicentre case–control study

AU - Ferini-Strambi, Luigi

AU - Oertel, Wolfgang

AU - Dauvilliers, Yves

AU - Postuma, Ronald B

AU - Marelli, Sara

AU - Iranzo, Alex

AU - Arnulf, Isabelle

AU - Birgit, Högl

AU - Manni, Raffaele

AU - Miyamoto, Tomoyuki

AU - Fantini, Maria-Livia

AU - Puligheddu, Monica

AU - Jennum, Poul

AU - Sonka, Karel

AU - Santamaria, Joan

AU - Zucconi, Marco

AU - Rancoita, Paola M V

AU - Leu-Semenescu, Smeranda

AU - Frauscher, Birgit

AU - Terzaghi, Michele

AU - Miyamoto, Masayuki

AU - Unger, Marcus

AU - Stiasny-Kolster, Karin

AU - Desautels, Alex

AU - Wolfson, Christina

AU - Pelletier, Amélie

AU - Montplaisir, Jacques

PY - 2014/6

Y1 - 2014/6

N2 - Patients with idiopathic REM sleep behavior disorder (iRBD) are at very high risk of developing neurodegenerative synucleinopathies, which are disorders with prominent autonomic dysfunction. Several studies have documented autonomic dysfunction in iRBD, but large-scale assessment of autonomic symptoms has never been systematically performed. Patients with polysomnography-confirmed iRBD (318 cases) and controls (137 healthy volunteers and 181 sleep center controls with sleep diagnoses other than RBD) were recruited from 13 neurological centers in 10 countries from 2008 to 2011. A validated scale to study the disorders of the autonomic nervous system in Parkinson's disease (PD) patients, the SCOPA-AUT, was administered to all the patients and controls. The SCOPA-AUT consists of 25 items assessing the following domains: gastrointestinal, urinary, cardiovascular, thermoregulatory, pupillomotor, and sexual dysfunction. Our results show that compared to control subjects with a similar overall age and sex distribution, patients with iRBD experience significantly more problems with gastrointestinal, urinary, and cardiovascular functioning. The most prominent differences in severity of autonomic symptoms between our iRBD patients and controls emerged in the gastrointestinal domain. Interestingly, it has been reported that an altered gastrointestinal motility can predate the motor phase of PD. The cardiovascular domain SCOPA-AUT score in our study in iRBD patients was intermediate with respect to the scores reported in PD patients by other authors. Our findings underline the importance of collecting data on autonomic symptoms in iRBD. These data may be used in prospective studies for evaluating the risk of developing neurodegenerative disorders.

AB - Patients with idiopathic REM sleep behavior disorder (iRBD) are at very high risk of developing neurodegenerative synucleinopathies, which are disorders with prominent autonomic dysfunction. Several studies have documented autonomic dysfunction in iRBD, but large-scale assessment of autonomic symptoms has never been systematically performed. Patients with polysomnography-confirmed iRBD (318 cases) and controls (137 healthy volunteers and 181 sleep center controls with sleep diagnoses other than RBD) were recruited from 13 neurological centers in 10 countries from 2008 to 2011. A validated scale to study the disorders of the autonomic nervous system in Parkinson's disease (PD) patients, the SCOPA-AUT, was administered to all the patients and controls. The SCOPA-AUT consists of 25 items assessing the following domains: gastrointestinal, urinary, cardiovascular, thermoregulatory, pupillomotor, and sexual dysfunction. Our results show that compared to control subjects with a similar overall age and sex distribution, patients with iRBD experience significantly more problems with gastrointestinal, urinary, and cardiovascular functioning. The most prominent differences in severity of autonomic symptoms between our iRBD patients and controls emerged in the gastrointestinal domain. Interestingly, it has been reported that an altered gastrointestinal motility can predate the motor phase of PD. The cardiovascular domain SCOPA-AUT score in our study in iRBD patients was intermediate with respect to the scores reported in PD patients by other authors. Our findings underline the importance of collecting data on autonomic symptoms in iRBD. These data may be used in prospective studies for evaluating the risk of developing neurodegenerative disorders.

KW - Aged

KW - Autonomic Nervous System Diseases

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Polysomnography

KW - REM Sleep Behavior Disorder

KW - Retrospective Studies

KW - Statistics, Nonparametric

U2 - 10.1007/s00415-014-7317-8

DO - 10.1007/s00415-014-7317-8

M3 - Letter

C2 - 24687894

SN - 0939-1517

VL - 261

SP - 1112

EP - 1118

JO - Deutsche Zeitschrift fur Nervenheilkunde

JF - Deutsche Zeitschrift fur Nervenheilkunde

IS - 6

ER -

Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case–control study

Abstract

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