Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta

H E Virtanen; J J Koskenniemi; E Sundqvist; K M Main; H Kiviranta; J T Tuomisto; J Tuomisto; M Viluksela; T Vartiainen; N E Skakkebaek; J Toppari

doi:10.1111/j.1365-2605.2011.01233.x

Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta

H E Virtanen, J J Koskenniemi, E Sundqvist, K M Main, H Kiviranta, J T Tuomisto, J Tuomisto, M Viluksela, T Vartiainen, N E Skakkebaek, J Toppari

Institut for Klinisk Medicin

32 Citationer (Scopus)

Abstract

In animal studies, exposure to dioxins has been associated with disrupted development of the male reproductive system, including testicular maldescent. Some polychlorinated biphenyls (PCBs) have also dioxin-like effects. In addition, one previous case-control study has reported an association between congenital cryptorchidism and colostrum PCB levels. We performed a case-control study to evaluate whether congenital cryptorchidism in boys was associated with increased levels of dioxins or PCBs in placenta reflecting foetal exposure. In addition, associations between placenta levels of these chemicals and reproductive hormone levels in boys at 3 months were studied. Placentas were collected in a Danish-Finnish joint prospective cohort study on cryptorchidism (1997-2001). The boys were examined for cryptorchidism at birth and at 3 months. Altogether, 280 placentas [112 Finnish (56 cases, 56 controls) and 168 Danish (39 cases, 129 controls)] were analysed for 17 toxic polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and 37 PCBs (including 12 dioxin-like PCBs). Infant serum samples taken at 3 months were analysed for reproductive hormones. No significant differences between cases and controls were observed in either country in dioxin WHO-TEq levels (median 9.78 vs. 8.47 pg/g fat, respectively, in Finland, and 11.75 vs. 10.88 pg/g fat in Denmark) or PCB WHO-TEq levels (median 2.12 vs. 2.15 pg/g fat in Finland, 2.34 vs. 2.10 pg/g fat in Denmark) or total-TEq levels (median 11.66 vs. 10.58 pg/g fat in Finland, 13.94 vs. 13.00 pg/g fat in Denmark). Placenta WHO-TEq levels of dioxins were not associated with infant reproductive hormone levels at 3 months. In Finland, PCB WHO-TEq levels in placenta associated positively with infant LH levels. WHO-TEq levels of dioxins and PCBs and total-TEq levels were higher in Danish than Finnish samples. In conclusion, no association between placenta levels of dioxins or PCBs and congenital cryptorchidism was found. Significant country differences in chemical levels were observed.

Originalsprog	Engelsk
Tidsskrift	International Journal of Andrology
Vol/bind	35
Udgave nummer	3
Sider (fra-til)	283-93
Antal sider	11
ISSN	0105-6263
DOI	https://doi.org/10.1111/j.1365-2605.2011.01233.x
Status	Udgivet - jun. 2012

Adgang til dokumentet

10.1111/j.1365-2605.2011.01233.x

Citationsformater

Virtanen, H. E., Koskenniemi, J. J., Sundqvist, E., Main, K. M., Kiviranta, H., Tuomisto, J. T., Tuomisto, J., Viluksela, M., Vartiainen, T., Skakkebaek, N. E., & Toppari, J. (2012). Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta. International Journal of Andrology, 35(3), 283-93. https://doi.org/10.1111/j.1365-2605.2011.01233.x

Virtanen, HE, Koskenniemi, JJ, Sundqvist, E, Main, KM, Kiviranta, H, Tuomisto, JT, Tuomisto, J, Viluksela, M, Vartiainen, T, Skakkebaek, NE & Toppari, J 2012, 'Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta', International Journal of Andrology, bind 35, nr. 3, s. 283-93. https://doi.org/10.1111/j.1365-2605.2011.01233.x

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title = "Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta",

abstract = "In animal studies, exposure to dioxins has been associated with disrupted development of the male reproductive system, including testicular maldescent. Some polychlorinated biphenyls (PCBs) have also dioxin-like effects. In addition, one previous case-control study has reported an association between congenital cryptorchidism and colostrum PCB levels. We performed a case-control study to evaluate whether congenital cryptorchidism in boys was associated with increased levels of dioxins or PCBs in placenta reflecting foetal exposure. In addition, associations between placenta levels of these chemicals and reproductive hormone levels in boys at 3 months were studied. Placentas were collected in a Danish-Finnish joint prospective cohort study on cryptorchidism (1997-2001). The boys were examined for cryptorchidism at birth and at 3 months. Altogether, 280 placentas [112 Finnish (56 cases, 56 controls) and 168 Danish (39 cases, 129 controls)] were analysed for 17 toxic polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and 37 PCBs (including 12 dioxin-like PCBs). Infant serum samples taken at 3 months were analysed for reproductive hormones. No significant differences between cases and controls were observed in either country in dioxin WHO-TEq levels (median 9.78 vs. 8.47 pg/g fat, respectively, in Finland, and 11.75 vs. 10.88 pg/g fat in Denmark) or PCB WHO-TEq levels (median 2.12 vs. 2.15 pg/g fat in Finland, 2.34 vs. 2.10 pg/g fat in Denmark) or total-TEq levels (median 11.66 vs. 10.58 pg/g fat in Finland, 13.94 vs. 13.00 pg/g fat in Denmark). Placenta WHO-TEq levels of dioxins were not associated with infant reproductive hormone levels at 3 months. In Finland, PCB WHO-TEq levels in placenta associated positively with infant LH levels. WHO-TEq levels of dioxins and PCBs and total-TEq levels were higher in Danish than Finnish samples. In conclusion, no association between placenta levels of dioxins or PCBs and congenital cryptorchidism was found. Significant country differences in chemical levels were observed.",

author = "Virtanen, {H E} and Koskenniemi, {J J} and E Sundqvist and Main, {K M} and H Kiviranta and Tuomisto, {J T} and J Tuomisto and M Viluksela and T Vartiainen and Skakkebaek, {N E} and J Toppari",

note = "{\textcopyright} 2011 The Authors. International Journal of Andrology {\textcopyright} 2011 European Academy of Andrology.",

year = "2012",

month = jun,

doi = "10.1111/j.1365-2605.2011.01233.x",

language = "English",

volume = "35",

pages = "283--93",

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T1 - Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta

AU - Virtanen, H E

AU - Koskenniemi, J J

AU - Sundqvist, E

AU - Main, K M

AU - Kiviranta, H

AU - Tuomisto, J T

AU - Tuomisto, J

AU - Viluksela, M

AU - Vartiainen, T

AU - Skakkebaek, N E

AU - Toppari, J

PY - 2012/6

Y1 - 2012/6

N2 - In animal studies, exposure to dioxins has been associated with disrupted development of the male reproductive system, including testicular maldescent. Some polychlorinated biphenyls (PCBs) have also dioxin-like effects. In addition, one previous case-control study has reported an association between congenital cryptorchidism and colostrum PCB levels. We performed a case-control study to evaluate whether congenital cryptorchidism in boys was associated with increased levels of dioxins or PCBs in placenta reflecting foetal exposure. In addition, associations between placenta levels of these chemicals and reproductive hormone levels in boys at 3 months were studied. Placentas were collected in a Danish-Finnish joint prospective cohort study on cryptorchidism (1997-2001). The boys were examined for cryptorchidism at birth and at 3 months. Altogether, 280 placentas [112 Finnish (56 cases, 56 controls) and 168 Danish (39 cases, 129 controls)] were analysed for 17 toxic polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and 37 PCBs (including 12 dioxin-like PCBs). Infant serum samples taken at 3 months were analysed for reproductive hormones. No significant differences between cases and controls were observed in either country in dioxin WHO-TEq levels (median 9.78 vs. 8.47 pg/g fat, respectively, in Finland, and 11.75 vs. 10.88 pg/g fat in Denmark) or PCB WHO-TEq levels (median 2.12 vs. 2.15 pg/g fat in Finland, 2.34 vs. 2.10 pg/g fat in Denmark) or total-TEq levels (median 11.66 vs. 10.58 pg/g fat in Finland, 13.94 vs. 13.00 pg/g fat in Denmark). Placenta WHO-TEq levels of dioxins were not associated with infant reproductive hormone levels at 3 months. In Finland, PCB WHO-TEq levels in placenta associated positively with infant LH levels. WHO-TEq levels of dioxins and PCBs and total-TEq levels were higher in Danish than Finnish samples. In conclusion, no association between placenta levels of dioxins or PCBs and congenital cryptorchidism was found. Significant country differences in chemical levels were observed.

AB - In animal studies, exposure to dioxins has been associated with disrupted development of the male reproductive system, including testicular maldescent. Some polychlorinated biphenyls (PCBs) have also dioxin-like effects. In addition, one previous case-control study has reported an association between congenital cryptorchidism and colostrum PCB levels. We performed a case-control study to evaluate whether congenital cryptorchidism in boys was associated with increased levels of dioxins or PCBs in placenta reflecting foetal exposure. In addition, associations between placenta levels of these chemicals and reproductive hormone levels in boys at 3 months were studied. Placentas were collected in a Danish-Finnish joint prospective cohort study on cryptorchidism (1997-2001). The boys were examined for cryptorchidism at birth and at 3 months. Altogether, 280 placentas [112 Finnish (56 cases, 56 controls) and 168 Danish (39 cases, 129 controls)] were analysed for 17 toxic polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and 37 PCBs (including 12 dioxin-like PCBs). Infant serum samples taken at 3 months were analysed for reproductive hormones. No significant differences between cases and controls were observed in either country in dioxin WHO-TEq levels (median 9.78 vs. 8.47 pg/g fat, respectively, in Finland, and 11.75 vs. 10.88 pg/g fat in Denmark) or PCB WHO-TEq levels (median 2.12 vs. 2.15 pg/g fat in Finland, 2.34 vs. 2.10 pg/g fat in Denmark) or total-TEq levels (median 11.66 vs. 10.58 pg/g fat in Finland, 13.94 vs. 13.00 pg/g fat in Denmark). Placenta WHO-TEq levels of dioxins were not associated with infant reproductive hormone levels at 3 months. In Finland, PCB WHO-TEq levels in placenta associated positively with infant LH levels. WHO-TEq levels of dioxins and PCBs and total-TEq levels were higher in Danish than Finnish samples. In conclusion, no association between placenta levels of dioxins or PCBs and congenital cryptorchidism was found. Significant country differences in chemical levels were observed.

U2 - 10.1111/j.1365-2605.2011.01233.x

DO - 10.1111/j.1365-2605.2011.01233.x

M3 - Journal article

C2 - 22150420

SN - 0105-6263

VL - 35

SP - 283

EP - 293

JO - International Journal of Andrology

JF - International Journal of Andrology

IS - 3

ER -

Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta

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