Association on DISC1 SNPs with schizophrenia risk: A meta-analysis

TY - JOUR

T1 - Association on DISC1 SNPs with schizophrenia risk: A meta-analysis

AU - Ma, J.-H.

AU - Sun, X.-Y.

AU - Guo, T.-J.

AU - Barot, Emily

AU - Wang, D.-F.

AU - Yan, L.-L.

AU - Ni, D.-W.

AU - Huang, N.-H.

AU - Xie, Q.

AU - Zeng, J.

AU - Ou-Yang, L.

AU - Liu, Y.-Q.

AU - Lu, Q.-B.

PY - 2018/12

Y1 - 2018/12

N2 - Schizophrenia is a major psychiatric disorder with complex genetic, environmental, and psychological etiologies. Although DISC1 gene has been shown as a risk factor for schizophrenia in some reports, there is a lack of a consensus. We therefore performed separate meta-analyses aiming to assess the associations between DISC1 SNPs and schizophrenia risk. We found that SNP rs821597 is significantly associated with schizophrenia risk in terms of both allelic and genotypic distribution, while SNP rs821616 is associated with schizophrenia in terms of genotypic distribution, especially in cases above 40 years old.

AB - Schizophrenia is a major psychiatric disorder with complex genetic, environmental, and psychological etiologies. Although DISC1 gene has been shown as a risk factor for schizophrenia in some reports, there is a lack of a consensus. We therefore performed separate meta-analyses aiming to assess the associations between DISC1 SNPs and schizophrenia risk. We found that SNP rs821597 is significantly associated with schizophrenia risk in terms of both allelic and genotypic distribution, while SNP rs821616 is associated with schizophrenia in terms of genotypic distribution, especially in cases above 40 years old.

U2 - 10.1016/j.psychres.2018.09.056

DO - 10.1016/j.psychres.2018.09.056

M3 - Journal article

C2 - 30286368

SN - 0165-1781

VL - 270

SP - 306

EP - 309

JO - Psychiatry Research

JF - Psychiatry Research

ER -