Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS)

TY - JOUR

T1 - Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS)

AU - van Vught, Anneke J A H

AU - Heitmann, Berit L

AU - Nieuwenhuizen, Arie G

AU - Veldhorst, Margriet A B

AU - Andersen, Lars Bo

AU - Hasselstrom, Henriette

AU - Brummer, Robert-Jan M

AU - Westerterp-Plantenga, Margriet S

PY - 2010

Y1 - 2010

N2 - Objective Growth hormone (GH) affects linear growth and body composition, by increasing the secretion of insulin-like growth factor-I (IGF-I), muscle protein synthesis and lipolysis. The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion. The present paper aimed to investigate associations between PROT intake as well as intake of the specific amino acids ARG and LYS, and subsequent 3-year-change in linear growth and body composition among 6-year-old children.Design Childrens data were collected from Copenhagen (Denmark), during 2001-2002, and again 3 years later. Boys and girls were separated into normal weight and overweight, based on BMI quintiles. Fat-free mass index (FFMI) and fat mass index (FMI) were calculated. Associations between change (Δ) in height, FMI and FFMI, respectively, and habitual PROT intake as well as ARG and LYS were analysed by multiple linear regressions, adjusted for baseline height, FMI or FFMI and energy intake, age, physical activity and socio-economic status.Setting Eighteen schools in two suburban communities in the Copenhagen (Denmark) area participated in the study.Subjects In all, 223 childrens data were collected for the present study.Results High ARG intake was associated with linear growth (β = 1.09 (se 0.54), P = 0.05) among girls. Furthermore, in girls, ΔFMI had a stronger inverse association with high ARG intake, if it was combined with high LYS intake, instead of low LYS intake (P = 0.03). No associations were found in boys.Conclusion In prepubertal girls, linear growth may be influenced by habitual ARG intake and body fat gain may be relatively prevented over time by the intake of the amino acids ARG and LYS.

AB - Objective Growth hormone (GH) affects linear growth and body composition, by increasing the secretion of insulin-like growth factor-I (IGF-I), muscle protein synthesis and lipolysis. The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion. The present paper aimed to investigate associations between PROT intake as well as intake of the specific amino acids ARG and LYS, and subsequent 3-year-change in linear growth and body composition among 6-year-old children.Design Childrens data were collected from Copenhagen (Denmark), during 2001-2002, and again 3 years later. Boys and girls were separated into normal weight and overweight, based on BMI quintiles. Fat-free mass index (FFMI) and fat mass index (FMI) were calculated. Associations between change (Δ) in height, FMI and FFMI, respectively, and habitual PROT intake as well as ARG and LYS were analysed by multiple linear regressions, adjusted for baseline height, FMI or FFMI and energy intake, age, physical activity and socio-economic status.Setting Eighteen schools in two suburban communities in the Copenhagen (Denmark) area participated in the study.Subjects In all, 223 childrens data were collected for the present study.Results High ARG intake was associated with linear growth (β = 1.09 (se 0.54), P = 0.05) among girls. Furthermore, in girls, ΔFMI had a stronger inverse association with high ARG intake, if it was combined with high LYS intake, instead of low LYS intake (P = 0.03). No associations were found in boys.Conclusion In prepubertal girls, linear growth may be influenced by habitual ARG intake and body fat gain may be relatively prevented over time by the intake of the amino acids ARG and LYS.

M3 - Journal article

SN - 1368-9800

VL - 13

SP - 647

EP - 653

JO - Public Health Nutrition

JF - Public Health Nutrition

IS - 5

ER -