Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances

Birgit Bjerre Høyer; Cecilia Høst Ramlau-Hansen; Martine Vrijheid; Damaskini Valvi; Henning Sloth Pedersen; Valentyna Zviezdai; Bo A G Jönsson; Christian H Lindh; Jens Peter Bonde; Gunnar Toft

doi:10.1289/ehp.1408881

Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances

Birgit Bjerre Høyer, Cecilia Høst Ramlau-Hansen, Martine Vrijheid, Damaskini Valvi, Henning Sloth Pedersen, Valentyna Zviezdai, Bo A G Jönsson, Christian H Lindh, Jens Peter Bonde, Gunnar Toft

Institut for Folkesundhedsvidenskab

49 Citationer (Scopus)

Abstract

BACKGROUND: In some animal studies, perfluorinated alkyl substances are suggested to induce weight gain. Human epidemiological studies investigating these associations are sparse.

OBJECTIVE: We examined pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and the prevalence of offspring overweight (> 1 SD) and waist-to-height ratio (WHtR) > 0.5 at 5-9 years of age.

METHODS: Sera from 1,022 pregnant women enrolled in the INUENDO cohort (2002-2004) from Greenland and Kharkiv (Ukraine) were analyzed for PFOA and PFOS using liquid chromatography-tandem mass spectrometry. Relative risks (RR) of being overweight and having WHtR > 0.5 in relation to continuous and categorized (tertiles) PFOA and PFOS were calculated at follow-up (2010-2012) using generalized linear models.

RESULTS: Pooled PFOA median (range) was 1.3 (0.2-5.1) and PFOS median (range) was 10.8 (0.8-73.0) ng/mL. For each natural logarithm-unit (ln-unit) increase of pregnancy PFOA, the adjusted RR of offspring overweight was 1.11 [95% confidence interval (CI): 0.82, 1.53] in Greenlandic children. In Ukrainian children, the adjusted RR of offspring overweight was 1.02 (95% CI: 0.72, 1.44) for each ln-unit increase of pregnancy PFOA. Prenatal exposure to PFOS was not associated with overweight in country-specific or pooled analysis. The adjusted RR of having WHtR > 0.5 for each ln-unit increase of prenatal exposure to PFOA was 1.30 (95% CI: 0.97, 1.74) in the pooled analysis. For 1-ln-unit increase of prenatal exposure to PFOS, the adjusted RR of having a WHtR > 0.5 was 1.38 (95% CI: 1.05, 1.82) in the pooled analysis.

CONCLUSIONS: The results indicate that prenatal PFOA and PFOS exposures may be associated with child waist-to-height ratio > 0.5. Prenatal PFOA and PFOS exposures were not associated with overweight.

Originalsprog	Engelsk
Tidsskrift	Environmental Health Perspectives
Vol/bind	123
Udgave nummer	8
Sider (fra-til)	841-6
Antal sider	6
ISSN	0091-6765
DOI	https://doi.org/10.1289/ehp.1408881
Status	Udgivet - 4 aug. 2015

Adgang til dokumentet

10.1289/ehp.1408881

http://europepmc.org/articles/pmc4529015?pdf=render

Citationsformater

Høyer, B. B., Ramlau-Hansen, C. H., Vrijheid, M., Valvi, D., Pedersen, H. S., Zviezdai, V., Jönsson, B. A. G., Lindh, C. H., Bonde, J. P., & Toft, G. (2015). Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances. Environmental Health Perspectives, 123(8), 841-6. https://doi.org/10.1289/ehp.1408881

Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances. / Høyer, Birgit Bjerre; Ramlau-Hansen, Cecilia Høst; Vrijheid, Martine et al.

I: Environmental Health Perspectives, Bind 123, Nr. 8, 04.08.2015, s. 841-6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Høyer, BB, Ramlau-Hansen, CH, Vrijheid, M, Valvi, D, Pedersen, HS, Zviezdai, V, Jönsson, BAG, Lindh, CH, Bonde, JP & Toft, G 2015, 'Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances', Environmental Health Perspectives, bind 123, nr. 8, s. 841-6. https://doi.org/10.1289/ehp.1408881

@article{fb07570197f84daf814535bca16ecfba,

title = "Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances",

abstract = "BACKGROUND: In some animal studies, perfluorinated alkyl substances are suggested to induce weight gain. Human epidemiological studies investigating these associations are sparse.OBJECTIVE: We examined pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and the prevalence of offspring overweight (> 1 SD) and waist-to-height ratio (WHtR) > 0.5 at 5-9 years of age.METHODS: Sera from 1,022 pregnant women enrolled in the INUENDO cohort (2002-2004) from Greenland and Kharkiv (Ukraine) were analyzed for PFOA and PFOS using liquid chromatography-tandem mass spectrometry. Relative risks (RR) of being overweight and having WHtR > 0.5 in relation to continuous and categorized (tertiles) PFOA and PFOS were calculated at follow-up (2010-2012) using generalized linear models.RESULTS: Pooled PFOA median (range) was 1.3 (0.2-5.1) and PFOS median (range) was 10.8 (0.8-73.0) ng/mL. For each natural logarithm-unit (ln-unit) increase of pregnancy PFOA, the adjusted RR of offspring overweight was 1.11 [95% confidence interval (CI): 0.82, 1.53] in Greenlandic children. In Ukrainian children, the adjusted RR of offspring overweight was 1.02 (95% CI: 0.72, 1.44) for each ln-unit increase of pregnancy PFOA. Prenatal exposure to PFOS was not associated with overweight in country-specific or pooled analysis. The adjusted RR of having WHtR > 0.5 for each ln-unit increase of prenatal exposure to PFOA was 1.30 (95% CI: 0.97, 1.74) in the pooled analysis. For 1-ln-unit increase of prenatal exposure to PFOS, the adjusted RR of having a WHtR > 0.5 was 1.38 (95% CI: 1.05, 1.82) in the pooled analysis.CONCLUSIONS: The results indicate that prenatal PFOA and PFOS exposures may be associated with child waist-to-height ratio > 0.5. Prenatal PFOA and PFOS exposures were not associated with overweight.",

keywords = "Alkanesulfonic Acids, Anthropometry, Caprylates, Child, Child, Preschool, Environmental Exposure, Environmental Pollutants, Female, Fluorocarbons, Greenland, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects, Ukraine",

author = "H{\o}yer, {Birgit Bjerre} and Ramlau-Hansen, {Cecilia H{\o}st} and Martine Vrijheid and Damaskini Valvi and Pedersen, {Henning Sloth} and Valentyna Zviezdai and J{\"o}nsson, {Bo A G} and Lindh, {Christian H} and Bonde, {Jens Peter} and Gunnar Toft",

year = "2015",

month = aug,

day = "4",

doi = "10.1289/ehp.1408881",

language = "English",

volume = "123",

pages = "841--6",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "National Institute of Environmental Health Sciences",

number = "8",

}

TY - JOUR

T1 - Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances

AU - Høyer, Birgit Bjerre

AU - Ramlau-Hansen, Cecilia Høst

AU - Vrijheid, Martine

AU - Valvi, Damaskini

AU - Pedersen, Henning Sloth

AU - Zviezdai, Valentyna

AU - Jönsson, Bo A G

AU - Lindh, Christian H

AU - Bonde, Jens Peter

AU - Toft, Gunnar

PY - 2015/8/4

Y1 - 2015/8/4

N2 - BACKGROUND: In some animal studies, perfluorinated alkyl substances are suggested to induce weight gain. Human epidemiological studies investigating these associations are sparse.OBJECTIVE: We examined pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and the prevalence of offspring overweight (> 1 SD) and waist-to-height ratio (WHtR) > 0.5 at 5-9 years of age.METHODS: Sera from 1,022 pregnant women enrolled in the INUENDO cohort (2002-2004) from Greenland and Kharkiv (Ukraine) were analyzed for PFOA and PFOS using liquid chromatography-tandem mass spectrometry. Relative risks (RR) of being overweight and having WHtR > 0.5 in relation to continuous and categorized (tertiles) PFOA and PFOS were calculated at follow-up (2010-2012) using generalized linear models.RESULTS: Pooled PFOA median (range) was 1.3 (0.2-5.1) and PFOS median (range) was 10.8 (0.8-73.0) ng/mL. For each natural logarithm-unit (ln-unit) increase of pregnancy PFOA, the adjusted RR of offspring overweight was 1.11 [95% confidence interval (CI): 0.82, 1.53] in Greenlandic children. In Ukrainian children, the adjusted RR of offspring overweight was 1.02 (95% CI: 0.72, 1.44) for each ln-unit increase of pregnancy PFOA. Prenatal exposure to PFOS was not associated with overweight in country-specific or pooled analysis. The adjusted RR of having WHtR > 0.5 for each ln-unit increase of prenatal exposure to PFOA was 1.30 (95% CI: 0.97, 1.74) in the pooled analysis. For 1-ln-unit increase of prenatal exposure to PFOS, the adjusted RR of having a WHtR > 0.5 was 1.38 (95% CI: 1.05, 1.82) in the pooled analysis.CONCLUSIONS: The results indicate that prenatal PFOA and PFOS exposures may be associated with child waist-to-height ratio > 0.5. Prenatal PFOA and PFOS exposures were not associated with overweight.

AB - BACKGROUND: In some animal studies, perfluorinated alkyl substances are suggested to induce weight gain. Human epidemiological studies investigating these associations are sparse.OBJECTIVE: We examined pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and the prevalence of offspring overweight (> 1 SD) and waist-to-height ratio (WHtR) > 0.5 at 5-9 years of age.METHODS: Sera from 1,022 pregnant women enrolled in the INUENDO cohort (2002-2004) from Greenland and Kharkiv (Ukraine) were analyzed for PFOA and PFOS using liquid chromatography-tandem mass spectrometry. Relative risks (RR) of being overweight and having WHtR > 0.5 in relation to continuous and categorized (tertiles) PFOA and PFOS were calculated at follow-up (2010-2012) using generalized linear models.RESULTS: Pooled PFOA median (range) was 1.3 (0.2-5.1) and PFOS median (range) was 10.8 (0.8-73.0) ng/mL. For each natural logarithm-unit (ln-unit) increase of pregnancy PFOA, the adjusted RR of offspring overweight was 1.11 [95% confidence interval (CI): 0.82, 1.53] in Greenlandic children. In Ukrainian children, the adjusted RR of offspring overweight was 1.02 (95% CI: 0.72, 1.44) for each ln-unit increase of pregnancy PFOA. Prenatal exposure to PFOS was not associated with overweight in country-specific or pooled analysis. The adjusted RR of having WHtR > 0.5 for each ln-unit increase of prenatal exposure to PFOA was 1.30 (95% CI: 0.97, 1.74) in the pooled analysis. For 1-ln-unit increase of prenatal exposure to PFOS, the adjusted RR of having a WHtR > 0.5 was 1.38 (95% CI: 1.05, 1.82) in the pooled analysis.CONCLUSIONS: The results indicate that prenatal PFOA and PFOS exposures may be associated with child waist-to-height ratio > 0.5. Prenatal PFOA and PFOS exposures were not associated with overweight.

KW - Alkanesulfonic Acids

KW - Anthropometry

KW - Caprylates

KW - Child

KW - Child, Preschool

KW - Environmental Exposure

KW - Environmental Pollutants

KW - Female

KW - Fluorocarbons

KW - Greenland

KW - Humans

KW - Male

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Ukraine

U2 - 10.1289/ehp.1408881

DO - 10.1289/ehp.1408881

M3 - Journal article

C2 - 25809098

SN - 0091-6765

VL - 123

SP - 841

EP - 846

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 8

ER -

Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances

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