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Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors
Hans Bräuner-Osborne
, B Ebert, M R Brann, E Falch,
P Krogsgaard-Larsen
14
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Medicin og biovidenskab
5,6,7,8-tetrahydro-4H-isoxazolo(4,5-c)azepin-3-ol
93%
Brain
6%
Carbachol
14%
Esters
6%
Inhibitory Concentration 50
23%
Ligands
9%
Membranes
3%
Muscarinic M1 Receptors
9%
Muscarinic Receptors
42%
norarecoline
100%
oxotremorine M
32%
Pharmacology
25%
Pirenzepine
8%
Quinuclidinyl Benzilate
19%
Technology
4%
Kemiske forbindelser
Acetylcholine
41%
Agonist
12%
Alkyl Group
12%
Antagonist
11%
Carbachol
18%
Ester
7%
Ligand
11%
Oxotremorine M
46%
Parasympathomimetic Agent
48%
Pharmacological Effect
16%
Pirenzepine
20%
Secondary Amino Group
18%