Animal-free toxicology: the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies

Lisbeth E Knudsen

Animal-free toxicology: the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies

Afdeling for Miljø og Sundhed

8 Citationer (Scopus)

Abstract

Human data on exposure and adverse effects are the most appropriate for human risk assessment, and modern toxicology focuses on human pathway analysis and the development of human biomarkers. Human biomonitoring and human placental transport studies provide necessary information for human risk assessment, in accordance with the legislation on chemical, medicine and food safety. Toxicology studies based on human mechanistic and exposure information can replace animal studies. These animal-free approaches can be further supplemented by new in silico methods and chemical structure-activity relationships. The inclusion of replacement expertise in the international Three Rs centres, the ongoing exploration of alternatives to animal research, and the improvement of conditions for research animals, all imply the beginning of a paradigm shift in toxicology research toward the use of human data.

Originalsprog	Engelsk
Tidsskrift	Alternatives to Laboratory Animals
Vol/bind	41
Udgave nummer	6
Sider (fra-til)	443-7
Antal sider	5
ISSN	0261-1929
Status	Udgivet - dec. 2013

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http://www.ncbi.nlm.nih.gov/pubmed/24512227

Citationsformater

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title = "Animal-free toxicology: the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies",

abstract = "Human data on exposure and adverse effects are the most appropriate for human risk assessment, and modern toxicology focuses on human pathway analysis and the development of human biomarkers. Human biomonitoring and human placental transport studies provide necessary information for human risk assessment, in accordance with the legislation on chemical, medicine and food safety. Toxicology studies based on human mechanistic and exposure information can replace animal studies. These animal-free approaches can be further supplemented by new in silico methods and chemical structure-activity relationships. The inclusion of replacement expertise in the international Three Rs centres, the ongoing exploration of alternatives to animal research, and the improvement of conditions for research animals, all imply the beginning of a paradigm shift in toxicology research toward the use of human data.",

author = "Knudsen, {Lisbeth E}",

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AU - Knudsen, Lisbeth E

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PY - 2013/12

Y1 - 2013/12

N2 - Human data on exposure and adverse effects are the most appropriate for human risk assessment, and modern toxicology focuses on human pathway analysis and the development of human biomarkers. Human biomonitoring and human placental transport studies provide necessary information for human risk assessment, in accordance with the legislation on chemical, medicine and food safety. Toxicology studies based on human mechanistic and exposure information can replace animal studies. These animal-free approaches can be further supplemented by new in silico methods and chemical structure-activity relationships. The inclusion of replacement expertise in the international Three Rs centres, the ongoing exploration of alternatives to animal research, and the improvement of conditions for research animals, all imply the beginning of a paradigm shift in toxicology research toward the use of human data.

AB - Human data on exposure and adverse effects are the most appropriate for human risk assessment, and modern toxicology focuses on human pathway analysis and the development of human biomarkers. Human biomonitoring and human placental transport studies provide necessary information for human risk assessment, in accordance with the legislation on chemical, medicine and food safety. Toxicology studies based on human mechanistic and exposure information can replace animal studies. These animal-free approaches can be further supplemented by new in silico methods and chemical structure-activity relationships. The inclusion of replacement expertise in the international Three Rs centres, the ongoing exploration of alternatives to animal research, and the improvement of conditions for research animals, all imply the beginning of a paradigm shift in toxicology research toward the use of human data.

M3 - Journal article

C2 - 24512227

SN - 0261-1929

VL - 41

SP - 443

EP - 447

JO - ATLA Alternatives to Laboratory Animals

JF - ATLA Alternatives to Laboratory Animals

IS - 6

ER -

Animal-free toxicology: the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies

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