An antileishmanial chalcone from Chinese licorice roots

TY - JOUR

T1 - An antileishmanial chalcone from Chinese licorice roots

AU - Christensen, S B

AU - Ming, C

AU - Andersen, L

AU - Hjørne, U

AU - Olsen, C E

AU - Cornett, C

AU - Theander, T G

AU - Kharazmi, A

N1 - Keywords: Animals; Antiprotozoal Agents; Chalcone; Chalcones; China; Glycyrrhiza; Leishmania donovani; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal

PY - 1994

Y1 - 1994

N2 - A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.

AB - A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.

M3 - Journal article

C2 - 8202561

SN - 0032-0943

VL - 60

SP - 121

EP - 123

JO - Planta Medica

JF - Planta Medica

IS - 2

ER -