@article{b3ddd650e88411ddbf70000ea68e967b,
title = "A ribosomal protein L23-nucleophosmin circuit coordinates Miz1 function with cell growth",
abstract = "The Myc-associated zinc-finger protein, Miz1, is a negative regulator of cell proliferation and induces expression of the cell-cycle inhibitors p15(Ink4b) and p21(Cip1). Here we identify the ribosomal protein L23 as a negative regulator of Miz1-dependent transactivation. L23 exerts this function by retaining nucleophosmin, an essential co-activator of Miz1 required for Miz1-induced cell-cycle arrest, in the nucleolus. Mutant forms of nucleophosmin found in acute myeloid leukaemia fail to co-activate Miz1 and re-localize it to the cytosol. As L23 is encoded by a direct target gene of Myc, this regulatory circuit may provide a feedback mechanism that links translation of Myc target genes and cell growth to Miz1-dependent cell-cycle arrest.",
author = "Michael Wanzel and Russ, {Annika C} and Daniela Kleine-Kohlbrecher and Emanuela Colombo and Pier-Guiseppe Pelicci and Martin Eilers",
year = "2008",
doi = "10.1038/ncb1764",
language = "English",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "nature publishing group",
}