A novel PNA-monomer for recognition of thymine in triple-helix structures

TY - JOUR

T1 - A novel PNA-monomer for recognition of thymine in triple-helix structures

AU - Olsen, A. Goldbech

AU - Dahl, O.

AU - Nielsen, Peter E.

PY - 2003/10/21

Y1 - 2003/10/21

N2 - To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synthesized in 7 steps starting from commercially available dimethyl 2-oxoglutarate.

AB - To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synthesized in 7 steps starting from commercially available dimethyl 2-oxoglutarate.

KW - Base Pairing

KW - Binding Sites

KW - Nucleic Acid Conformation

KW - Peptide Nucleic Acids/chemical synthesis

KW - Thymine

U2 - 10.1081/NCN-120022958

DO - 10.1081/NCN-120022958

M3 - Journal article

C2 - 14565411

SN - 1525-7770

VL - 22

SP - 1331

EP - 1333

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 5-8

ER -