Krister Wennerberg

Publikation

Publikationer pr. år 2002 2014 2015 2016 2017 2018 2018

• 68 Tidsskriftartikel
• 7 Review

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2014

  Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

  Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumägi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, K. & Aittokallio, T., 5 jun. 2014, I: Scientific Reports. 4, s. 5193

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  • Pharmaceutical Preparations 100%
  • Therapeutics 39%
  • Neoplasms 38%
  • Leukemia 32%
  • Theoretical Models 32%
  118 Citationer (Scopus)

• The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine

  Pietiainen, V., Saarela, J., von Schantz, C., Turunen, L., Ostling, P. & Wennerberg, K., maj 2014, I: Combinatorial Chemistry & High Throughput Screening. 17, 4, s. 377-86 10 s.

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  • Personalized medicine 100%
  • Molecular Medicine 99%
  • Silencing RNA 89%
  • Finland 75%
  • Precision Medicine 74%
  6 Citationer (Scopus)

• Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

  Antila, H., Autio, H., Turunen, L., Harju, K., Tammela, P., Wennerberg, K., Yli-Kauhaluoma, J., Huttunen, H. J., Castrén, E. & Rantamäki, T., 30 jan. 2014, I: Journal of Neuroscience Methods. 222, s. 142-6 5 s.

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  • Cultured Cells 100%
  • Enzyme-Linked Immunosorbent Assay 83%
  • Phosphorylation 81%
  • Intracellular Signaling Peptides and Proteins 31%
  • Nerve Growth Factors 21%
  5 Citationer (Scopus)
• 2013

  A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis

  Wolfe, L. M., Veeraraghavan, U., Idicula-Thomas, S., Schürer, S., Wennerberg, K., Reynolds, R., Besra, G. S. & Dobos, K. M., jun. 2013, I: Molecular and Cellular Proteomics. 12, 6, s. 1644-60 17 s.

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  • Proteome 100%
  • Mycobacterium tuberculosis 93%
  • Proteomics 88%
  • Adenosine Triphosphate 74%
  • Metabolic 58%
  29 Citationer (Scopus)

• Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

  Rajala, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, K., Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 maj 2013, I: Blood. 121, 22, s. 4541-50 10 s.

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  • Large Granular Lymphocytic Leukemia 100%
  • Mutation 54%
  • STAT3 Transcription Factor 22%
  • Genes 11%
  • Exome 11%
  172 Citationer (Scopus)

• Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia

  Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundán, T., Majumder, M. M., Marti, J. M. L., Mattila, P., & 16 flereMurumägi, A., Mustjoki, S., Palva, A., Parsons, A., Pirttinen, T., Rämet, M. E., Suvela, M., Turunen, L., Västrik, I., Wolf, M., Knowles, J., Aittokallio, T., Heckman, C. A., Porkka, K., Kallioniemi, O. & Wennerberg, K., dec. 2013, I: Cancer Discovery. 3, 12, s. 1416-29 14 s.

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  • Systems Analysis 100%
  • Precision Medicine 95%
  • Acute Myeloid Leukemia 84%
  • Drug Resistance 67%
  • Pharmaceutical Preparations 36%
  212 Citationer (Scopus)

• Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways

  Tang, J., Karhinen, L., Xu, T., Szwajda, A., Yadav, B., Wennerberg, K. & Aittokallio, T., sep. 2013, I: PLOS Computational Biology. 9, 9, s. e1003226

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  • Pathway 100%
  • Cancer 85%
  • Drugs 85%
  • cancer 78%
  • Target 71%
  64 Citationer (Scopus)
• 2012

  Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs

  Khan, S. A., Faisal, A., Mpindi, J. P., Parkkinen, J. A., Kalliokoski, T., Poso, A., Kallioniemi, O. P., Wennerberg, K. & Kaski, S., 30 maj 2012, I: BMC Bioinformatics. 13, s. 112

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  • Cheminformatics 100%
  • Data-driven 69%
  • Genome 67%
  • Genomics 63%
  • Cancer 63%
  15 Citationer (Scopus)

• Somatic STAT3 mutations in large granular lymphocytic leukemia

  Koskela, H. L. M., Eldfors, S., Ellonen, P., van Adrichem, A. J., Kuusanmäki, H., Andersson, E. I., Lagström, S., Clemente, M. J., Olson, T., Jalkanen, S. E., Majumder, M. M., Almusa, H., Edgren, H., Lepistö, M., Mattila, P., Guinta, K., Koistinen, P., Kuittinen, T., Penttinen, K., Parsons, A., & 9 flereKnowles, J., Saarela, J., Wennerberg, K., Kallioniemi, O., Porkka, K., Loughran, T. P., Heckman, C. A., Maciejewski, J. P. & Mustjoki, S., 17 maj 2012, I: The New England Journal of Medicine. 366, 20, s. 1905-13 9 s.

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  • Large Granular Lymphocytic Leukemia 100%
  • STAT3 Transcription Factor 78%
  • Mutation 36%
  • Genes 26%
  • Dimerization 18%
  463 Citationer (Scopus)
• 2011

  Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening

  Manuvakhova, M. S., Johnson, G. G., White, M. C., Ananthan, S., Sosa, M., Maddox, C., McKellip, S., Rasmussen, L., Wennerberg, K., Hobrath, J. V., White, E. L., Maddry, J. A. & Grimaldi, M., jan. 2011, I: Journal of Neuroscience Research. 89, 1, s. 58-72 15 s.

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  • Neurons 100%
  • Glutamic Acid 95%
  • Cytokine Receptors 65%
  • Astrocytes 49%
  • Cluster Analysis 48%
  15 Citationer (Scopus)
• 2010

  A high-throughput screen for chemical inhibitors of exocytic transport in yeast

  Zhang, L., Nebane, N. M., Wennerberg, K., Li, Y., Neubauer, V., Hobrath, J. V., McKellip, S., Rasmussen, L., Shindo, N., Sosa, M., Maddry, J. A., Ananthan, S., Piazza, G. A., White, E. L. & Harsay, E., 14 jun. 2010, I: ChemBioChem. 11, 9, s. 1291-301 11 s.

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  • Mutation 100%
  • Yeasts 95%
  • Transport Vesicles 30%
  • Endosomes 26%
  • Pump 22%
  5 Citationer (Scopus)
• 2008

  MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF

  Swenson-Fields, K. I., Sandquist, J. C., Rossol-Allison, J., Blat, I. C., Wennerberg, K., Burridge, K. & Means, A. R., 10 okt. 2008, I: Molecular Cell. 32, 1, s. 43-56 14 s.

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  • mitogen-activated protein kinase kinase kinase 11 100%
  • Cell Movement 15%
  • rho GTP-Binding Proteins 11%
  • Phosphotransferases 7%
  34 Citationer (Scopus)
• 2007

  A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin

  Dubash, A. D., Wennerberg, K., García-Mata, R., Menold, M. M., Arthur, W. T. & Burridge, K., 15 nov. 2007, I: Journal of Cell Science. 120, Pt 22, s. 3989-98 10 s.

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  • Rho Guanine Nucleotide Exchange Factors 100%
  • Fibronectins 63%
  • Stress Fibers 27%
  • Focal Adhesions 25%
  • Guanine Nucleotide Exchange Factors 14%
  96 Citationer (Scopus)
• 2006

  Analysis of activated GAPs and GEFs in cell lysates

  García-Mata, R., Wennerberg, K., Arthur, W. T., Noren, N. K., Ellerbroek, S. M. & Burridge, K., 2006, I: Methods in Enzymology. 406, s. 425-37 13 s.

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  • GTP Phosphohydrolases 100%
  • Effector 95%
  146 Citationer (Scopus)
• 2005

  The Ras superfamily at a glance

  Wennerberg, K., Rossman, K. L. & Der, C. J., 1 mar. 2005, I: Journal of Cell Science. 118, Pt 5, s. 843-6 4 s.

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  865 Citationer (Scopus)
• 2004

  p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation

  Aitsebaomo, J., Wennerberg, K., Der, C. J., Zhang, C., Kedar, V., Moser, M., Kingsley-Kallesen, M. L., Zeng, G-Q. & Patterson, C., 23 apr. 2004, I: The Journal of Biological Chemistry. 279, 17, s. 17963-72 10 s.

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  • GTPase-Activating Proteins 100%
  • Zinc Fingers 83%
  • Endothelial Cells 54%
  • Endothelin-1 47%
  • Blood Vessels 43%
  23 Citationer (Scopus)

• Rho and Rac take center stage

  Burridge, K. & Wennerberg, K., 23 jan. 2004, I: Cell. 116, 2, s. 167-79 13 s.

  Publikation: Bidrag til tidsskrift › Review › peer review

  • Actin Cytoskeleton 100%
  • Protein 83%
  • Proteins 74%
  • GTPase-Activating Proteins 68%
  • Guanine Nucleotide Exchange Factors 66%
  1451 Citationer (Scopus)

• Rho-family GTPases: it's not only Rac and Rho (and I like it)

  Wennerberg, K. & Der, C. J., 15 mar. 2004, I: Journal of Cell Science. 117, Pt 8, s. 1301-12 12 s.

  Publikation: Bidrag til tidsskrift › Review › peer review

  • rho GTP-Binding Proteins 100%
  • Protein Isoforms 64%
  • Monomeric GTP-Binding Proteins 46%
  • GTP Phosphohydrolases 45%
  • Guanosine Triphosphate 42%
  410 Citationer (Scopus)

• SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis

  Ellerbroek, S. M., Wennerberg, K., Arthur, W. T., Dunty, J. M., Bowman, D. R., DeMali, K. A., Der, C. & Burridge, K., jul. 2004, I: Molecular Biology of the Cell. 15, 7, s. 3309-19 11 s.

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  • Guanine Nucleotide Exchange Factors 100%
  • Fibroblasts 20%
  • Membranes 16%
  • Dextrans 15%
  • Rho Guanine Nucleotide Exchange Factors 10%
  79 Citationer (Scopus)
• 2003

  Integrin signaling to the actin cytoskeleton

  DeMali, K. A., Wennerberg, K. & Burridge, K., okt. 2003, I: Current Opinion in Cell Biology. 15, 5, s. 572-82 11 s.

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  • Actin Cytoskeleton 100%
  • Integrins 95%
  • Actins 85%
  • Phosphatidylinositol 4,5-Diphosphate 77%
  • rho GTP-Binding Proteins 63%
  411 Citationer (Scopus)

• Rnd proteins function as RhoA antagonists by activating p190 RhoGAP

  Wennerberg, K., Forget, M-A., Ellerbroek, S. M., Arthur, W. T., Burridge, K., Settleman, J., Der, C. J. & Hansen, S. H., 1 jul. 2003, I: Current biology : CB. 13, 13, s. 1106-15 10 s.

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  • Antagonist 100%
  • antagonists 92%
  • GTPase-activating proteins 77%
  • GTPase-Activating Proteins 72%
  • Protein 44%
  170 Citationer (Scopus)

• Serine phosphorylation negatively regulates RhoA in vivo

  Ellerbroek, S. M., Wennerberg, K. & Burridge, K., 23 maj 2003, I: The Journal of Biological Chemistry. 278, 21, s. 19023-31 9 s.

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  • rhoA GTP-Binding Protein 100%
  • Serine 82%
  • Clone Cells 68%
  • Phosphorylation 58%
  • GTPase-Activating Proteins 57%
  243 Citationer (Scopus)
• 2002

  Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1

  Velling, T., Risteli, J., Wennerberg, K., Mosher, D. F. & Johansson, S., 4 okt. 2002, I: The Journal of Biological Chemistry. 277, 40, s. 37377-81 5 s.

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  • Integrin alpha1 100%
  • Fibronectin 67%
  • Collagen Type III 66%
  • Polymerization 57%
  • Collagen Type I 55%
  269 Citationer (Scopus)

• RhoG signals in parallel with Rac1 and Cdc42

  Wennerberg, K., Ellerbroek, S. M., Liu, R-Y., Karnoub, A. E., Burridge, K. & Der, C. J., 6 dec. 2002, I: The Journal of Biological Chemistry. 277, 49, s. 47810-7 8 s.

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  • Guanine Nucleotide Exchange Factors 100%
  • Pseudopodia 90%
  • Monomeric GTP-Binding Proteins 89%
  • Effector 82%
  • NF-kappa B 80%
  81 Citationer (Scopus)

• XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

  Arthur, W. T., Ellerbroek, S. M., Der, C. J., Burridge, K. & Wennerberg, K., 8 nov. 2002, I: The Journal of Biological Chemistry. 277, 45, s. 42964-72 9 s.

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  • Rho Guanine Nucleotide Exchange Factors 100%
  • Guanine Nucleotide Exchange Factors 85%
  • Guanine 63%
  • Nucleotide 53%
  • Guanosine Triphosphate 45%
  85 Citationer (Scopus)