Birger Brodin Larsen

Publikation

Publikationer pr. år 1989 2010 2014 2019

• 87 Tidsskriftartikel
• 52 Konferenceabstrakt til konference
• 13 Bidrag til bog/antologi
• 12 Poster
• 6 Mere
  • 4 Review
  • 1 Bog
  • 1 Konferenceabstrakt i tidsskrift

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2014

  PAT1 (SLC36A1) shows nuclear localization and affect growth of smooth muscle cells from rats

  Jensen, A., Figueiredo-Larsen, E. M., Holm, R., Broberg, M. L., Brodin, B. & Nielsen, C. U., 1 jan. 2014, I: A J P: Endocrinology and Metabolism (Online). 306, s. E65-E74

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Amino Acid Transport Systems 100%
  • Protons 74%
  • Smooth Muscle Myocytes 64%
  • Growth 37%
  • Aorta 9%
  14 Citationer (Scopus)

• The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers

  Nøhr, M. K., Hansen, S. H., Brodin, B., Holm, R. & Nielsen, C. U., 23 jan. 2014, I: European Journal of Pharmaceutical Sciences. 51, s. 1-10

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Vigabatrin 100%
  • Caco-2 Cells 82%
  • Pharmaceutical Preparations 28%
  • Protons 14%
  • Amino Acid Transport Systems 9%
  10 Citationer (Scopus)

• THE POSSIBLE EFFECT OF TELMISARTAN ON THE BLOOD-BRAIN BARRIER TRANSPORT OF VERAPAMIL.

  Saaby, L., Tfelt-Hansen, P. & Brodin, B., 18 sep. 2014. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• Transport pathways mediating blood-to-brain L-glutamate efflux

  Helms, H. C. C., Nielsen, C. U., Waagepetersen, H. S. & Brodin, B., 10 dec. 2014. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• VPS10P domain receptor trafficking in brain endothelial cells

  Siupka, P., Højland, A., Thomsen, L. B., Lykke-Hartmann, K., Helms, H. C. C., Brodin, B., Moos, T., Madsen, P. S. & Nielsen, M. S., 10 dec. 2014. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review
• 2013

  Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent

  Berthelsen, R., Nielsen, C. U. & Brodin, B., jul. 2013, I: Journal of Pharmacy and Pharmacology. 65, 7, s. 970-9 10 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • glycylsarcosine 100%
  • Caco-2 Cells 67%
  • Monolayer 43%
  • peptide permease 35%
  • Protons 35%
  15 Citationer (Scopus)

• Cellemodel af blodhjernebarrieren kan mindske brugen af forsøgsdyr

  Brodin, B., Helms, H. C. C., Hersom, M. N. S., Nielsen, C. U. & Waagepetersen, H. S., 2013, I: Lægemiddelforskning. 2013, s. 47-49 3 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Formidling

• Current status of rational design of prodrugs targeting the intestinal di/tri-peptide transporter hPEPT1 (SLC15A1)

  Saaby, L., Nielsen, C. U., Steffansen, B., Brodin, B. & Larsen, S. B. L., 2013, I: Journal of Drug Delivery Science and Technology. 23, 4, s. 307–314

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • peptide permease 100%
  • Dipeptides 83%
  • Prodrugs 71%
  • Tripeptide 70%
  • Prodrug 68%
  2 Citationer (Scopus)

• Endothelial cell phenotype differs strongly between in viro BCEC monocultures and BCEC/rat astrocyte co-cultures, a phenomenon which may contribute to the differences in barrier tightness

  Helms, H. C. C. & Brodin, B., 2013. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

  • Coculture Techniques 100%
  • Astrocytes 92%
  • Endothelial Cells 74%
  • Phenotype 60%

• Excitatory amino acid transporter-1 (EAAT1) is the main transporter responsible for abluminal uptake of L-glutamate in bovine brain endothelial cells

  Helms, H. C. C., Groth, S., Mikél, M., Waagepetersen, H. S., Nielsen, C. U. & Brodin, B., 27 maj 2013.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• Expression and functional activity of the efflux transporters BCRP and P-gp in bovine endothelial cells, co-cultured with rat astrocytes

  Hersom, M. N. S., Helms, H. C. C., Kuhlmann, L. B., Badolo, L. & Brodin, B., 2013. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

  • Astrocytes 100%
  • Cattle 87%
  • Endothelial Cells 80%

• Membrane Transporters in ADME

  Steffansen, B., Nielsen, C. U. & Brodin, B., 2013, Transporters in drug development: discovery, optimization, clinical study and regulation. Steffansen, B. & Sugiyama, Y. (red.). Springer Publishing Company, Bind 7. s. 1-22 (AAPS Advances in the Pharmaceutical Sciences Series).

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

• Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents

  Frølund, S. B., Nøhr, M. K., Holm, R., Brodin, B. & Nielsen, C. U., 2013, I: Journal of Drug Delivery Science and Technology. 23, 4, s. 293-306

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Amino Acid Transport Systems 100%
  • Protons 74%
  • alanylglycine 63%
  • gaboxadol 59%
  • Pharmaceutical 53%
  4 Citationer (Scopus)

• Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)

  Stafford, G. I., Birer, C., Brodin, B., Christensen, S. B., Eriksson, A. H., Jäger, A. & Rønsted, N., sep. 2013, I: South African Journal of Botany. 88, s. 101-106 6 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  7 Citationer (Scopus)

  58 Downloads (Pure)

• Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

  Nielsen, C. U., Frølund, S. B., Abdulhadi, S., Sari, H., Langthaler, L., Nøhr, M. K., Kall, M. A., Brodin, B. & Holm, R., nov. 2013, I: British Journal of Pharmacology. 170, 5, s. 1041-52 12 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Sertraline 100%
  • gaboxadol 37%
  • In Vitro Techniques 33%
  • Caco-2 Cells 20%
  • Protons 11%
  7 Citationer (Scopus)

• Vigabatrin absorption is mediated via the proton-coupled amino acid transporter PAT1 – in vitro and in vivo

  Nøhr, M. K., Juul, R. V., Hansen, S. H., Brodin, B., Holm, R., Kreilgaard, M. & Nielsen, C. U., 24 jun. 2013.

  Publikation: Konferencebidrag › Poster › Forskning

  • Vigabatrin 100%
  • Acid 20%
  • Monolayer 18%
  • Permeability 7%
  • Proton 6%
• 2012

  Carrier-mediated ¿-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers

  Nielsen, C. U., Carstensen, M. & Brodin, B., jun. 2012, I: European Journal of Pharmaceutics and Biopharmaceutics. 81, 2, s. 458-462

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Aminobutyrates 100%
  • Caco-2 Cells 80%
  • gamma-Aminobutyric Acid 65%
  • Monolayer 50%
  • Membranes 40%
  8 Citationer (Scopus)

• Function and expression of the proton-coupled amino acid transporter Slc36a1 along the rat gastrointestinal tract: Implications for intestinal absorption of gaboxadol

  Broberg, M. L., Holm, R. K., Tønsberg, H., Frølund, S. B., Ewon, K. B., Nielsen, A. L., Brodin, B., Jensen, A., Kall, M. A., Nielsen, C. U. & Christensen, K. V., okt. 2012, I: British Journal of Pharmacology. 167, 3, s. 654-665

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • gaboxadol 100%
  • Amino Acid Transport Systems 84%
  • Intestinal Absorption 70%
  • Protons 63%
  • Gastrointestinal Tract 53%
  24 Citationer (Scopus)

• Generation of a rat in-vitro blood-brain barrier model and initial insights on excitatory amino acid transporter expression

  Groth, S., Moos, T., Helms, H. C. C. & Brodin, B., 2012. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• Glutamate efflux from brain to blood - Studies in an in vitro blood-brain barrier model

  Helms, H. C. C., Madelung, R., Waagepetersen, H. S., Nielsen, C. U. & Brodin, B., 2012.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1

  Søndergaard, H. B., Nielsen, C. U. & Brodin, B., 31 dec. 2012, I: International Journal of Peptides. 2012, 2012, 7 s., 743472.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Tripeptide 100%
  • Peptidomimetics 66%
  • Dipeptides 59%
  • Peptidomimetic 55%
  • Caco-2 Cells 53%
  1 Citationer (Scopus)

• In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids

  Eriksson, A. H., Rønsted, N., Jäger, A. K., Sendra, J. R. & Brodin, B., nov. 2012, I: Journal of Pharmacy and Pharmacology. 64, 11, s. 1667-1677 11 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Amaryllidaceae Alkaloids 100%
  • Galanthamine 83%
  • Crinine 66%
  • Lycorine 58%
  • Serotonin 58%
  12 Citationer (Scopus)

• In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

  Helms, H. C., Madelung, R., Waagepetersen, H. S., Nielsen, C. U. & Brodin, B., maj 2012, I: Glia. 60, 6, s. 882-893

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Astrocytes 100%
  • Glutamic Acid 95%
  • Endothelial Cells 80%
  • Aspartic Acid 64%
  • Brain 53%
  57 Citationer (Scopus)

• In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells co-cultured with astrocytes display a polarized brain-to-blood transport of glutamate

  Helms, H. C. C., Madelung, R., Groth, S., Waagepetersen, H. S., Nielsen, C. U. & Brodin, B., 13 sep. 2012. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• In-vitro models of the blood brain barrier

  Brodin, B., Helms, H. C. C., Groth, S., Waagepetersen, H. S. & Nielsen, C. U., 2012. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• Kostens sammensætning kan påvirke optagelsen af lægemiddelstoffer

  Nielsen, C. U., Frølund, S. B., Nøhr, M. K., Brodin, B. & Holm, R., 2012, I: Lægemiddelforskning. 2012, s. 31-33

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Formidling

• The proton-coupled amino acid transporter hPAT1 is the main transporter involved in vigabatrin uptake in intestinal Caco-2 cells

  Nøhr, M. K., Hansen, S. H., Brodin, B., Holm, R. & Nielsen, C. U., 30 nov. 2012.

  Publikation: Konferencebidrag › Poster › Forskning

  • amino acid transporters 100%
  • protons 71%
  • transporters 64%
  • uptake mechanisms 49%
  • cells 23%
• 2011

  Affinity and translocation relationships via hPEPT1 of H-X_aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs

  Omkvist, D. H., Trangbæk, D. J., Mildon, J., Paine, J. S., Larsen, B. B., Begtrup, M. & Nielsen, C. U., feb. 2011, I: European Journal of Pharmaceutics and Biopharmaceutics. 77, 2, s. 327-331

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • phenylalanylserine 100%
  • Benzoic Acid 64%
  • Dipeptides 59%
  • Ibuprofen 53%
  • Prodrugs 50%
  4 Citationer (Scopus)

• Bovine endothelial/rat astrocyte co-cultures cultured in highly buffered media functionally express MDR1 and BCRP

  Helms, H. C. C., Badolo, L., Kuhlmann, L. B. & Brodin, B., 21 jun. 2011.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances

  Stentebjerg-Andersen, A., Notlevesen, I. V., Larsen, B. B. & Nielsen, C. U., maj 2011, I: European Journal of Pharmaceutics and Biopharmaceutics. 78, 1, s. 19-26

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Dipeptides 100%
  • Dipeptide 77%
  • Air 62%
  • Liquid 41%
  • glycylsarcosine 38%
  25 Citationer (Scopus)

• Transport af lægemiddelstoffer gennem vævsbarrier

  Nielsen, C. U. & Brodin, B., 2011, Bioteknologi - en temabog. Gasbjerg, P. K., Jensen, G. S. & Sørensen, A. B. (red.). Århus: Systime, s. 145-157 12 s.

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Undervisning › peer review
• 2010

  5-Hydroxy-L-tryptohan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination

  Broberg, M. L., Holm, R., Jensen, K. G., Sveigaard, C., Larsen, B. B. & Nielsen, C. U., 31 jan. 2010, I: European Journal of Pharmaceutical Sciences. 39, 1-3, s. 68-75

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • gaboxadol 100%
  • 5-Hydroxytryptophan 60%
  • Pharmacokinetics 46%
  • Organic Anion 25%
  • Monolayer 15%
  18 Citationer (Scopus)

• Absorptive transporters

  Nielsen, C. U., Steffansen, B. & Larsen, B. B., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage from evaluation. Steffansen, B., Brodin, B. & Uhd Nielsen, C. (red.). London: Pharmaceutical Press, s. 193-211 (ULLA Pharmacy Series).

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

• Acid/base properties, solubility and distribution of drug candidates

  Steffansen, B., Nielsen, C. U. & Brodin, B., 2010, Molecular Biopharmaceutics: Aspects of drug characterization drug delivery and dosage form evaluation. Pharmaceutical Press, s. 5-31

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

• A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1)

  Omkvist, D. H., Larsen, S. B., Nielsen, C. U., Steffansen, B., Olsen, L., Jørgensen, F. S. & Larsen, B. B., sep. 2010, I: The AAPS Journal. 12, 3, s. 385-396

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • peptide permease 100%
  • Quantitative Structure-Activity Relationship 88%
  • Madin Darby Canine Kidney Cells 79%
  • Tripeptide 70%
  • QSAR Study 66%
  22 Citationer (Scopus)

• Carrier-mediated transport kinetics

  Nielsen, C. U., Steffansen, B. & Larsen, B. B., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Pharmaceutical Press, s. 153-173

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

• Claudin-5 mRNA expression and transendothelial electrical resistance (TEER) correlate in the BCEC/astrocyte blood-brain barrier model

  Helms, H. C. C., Waagepetersen, H. S., Nielsen, C. U. & Brodin, B., 2010. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

  • Claudin-5 100%
  • Electric Impedance 67%
  • Blood-Brain Barrier 64%
  • Astrocytes 61%
  • Messenger RNA 38%

• d-Aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)

  Frølund, S., Marquez, O. C., Larsen, M., Brodin, B. & Nielsen, C. U., mar. 2010, I: British Journal of Pharmacology. 159, 6, s. 1339-1353

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Amino Acid Transport Systems 100%
  • Aminolevulinic Acid 94%
  • Caco-2 Cells 26%
  • COS Cells 13%
  • Intestinal Absorption 12%
  39 Citationer (Scopus)

• Efflux transporters

  Nielsen, C. U., Larsen, B. B. & Steffansen, B., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Steffansen, B., Brodin, B. & Uhd Nielsen, C. (red.). Pharmaceutical Press, s. 213-22

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

• GABA transport across the basolateral membrane of intestinal cells

  Nielsen, C. U., Carstensen, M. & Larsen, B. B., 2010. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• Gly-Sar is a substrate for the human proton-coupled amino acid transporter, hPAT1 (SLC36A1)

  Frølund, S. B., Holm, R., Brodin, B. & Nielsen, C. U., mar. 2010.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• Gly-sar is a substrate for the human proton coupled amino acid trasporter 1, hPAT1 (SLC36A1)

  Frølund, S. B., Holm, R., Larsen, B. B. & Nielsen, C. U., 2010.

  Publikation: Konferencebidrag › Poster › Forskning

• Hjernens forsvarsmur kortlagt og kopieret

  Helms, H. C., Waagepetersen, H. S., Nielsen, C. U. & Larsen, B. B., 2010, I: Lægemiddelforskning. 2010, s. 22-24

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Formidling

  1687 Downloads (Pure)

• Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption

  Omkvist, D. H., Brodin, B. & Nielsen, C. U., mar. 2010. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption

  Omkvist, D. H., Larsen, B. B. & Nielsen, C. U., 2010.

  Publikation: Konferencebidrag › Poster › Forskning

• Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen

  Omkvist, D. H., Larsen, B. B. & Nielsen, C. U., dec. 2010, I: British Journal of Pharmacology. 161, 8, s. 1793-1805

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • peptide permease 100%
  • Ibuprofen 75%
  • glycylsarcosine 31%
  • Madin Darby Canine Kidney Cells 22%
  • Caco-2 Cells 21%
  23 Citationer (Scopus)

• Introduction

  Steffansen, B., Nielsen, C. U. & Larsen, B. B., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage from evaluation. Steffansen, B., Brodin, B. & Uhd Nielsen, C. (red.). London: Pharmaceutical Press, s. 1-4 4 s.

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

• In vitro models for investigating the function of proton-coupled amino acid transporter 1 (PAT1, SLC36A19)

  Jensen, A., Brodin, B. & Nielsen, C. U., 2010. 1 s.

  Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

• Kinetics of decomposition in aqueous solution

  Steffansen, B., Nielsen, C. U. & Larsen, B. B., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Steffansen, B., Brodin, B. & Nielsen, C. U. (red.). Pharmaceutical Press, s. 51-69 (ULLA Pharmacy Series).

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

• Mechanism of decomposition of drug candidates

  Steffansen, B., Nielsen, C. U. & Brodin, B., 2010, Molecular Biopharmaceutics: Aspects of drug characterization, drug delivery and dosage form evaluation. Pharmaceutical Press, s. 35-48 13 s. (ULLA Pharmacy Series).

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review